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| The immune function status and clinical outcomes of infertile patients with high-risk human papilloma virus infection after assisted reproductive technology |
| Hangzhou Hospital of Traditional Chinese Medicine, Zhejiang Province, 310007 |
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Abstract To investigate the immune function status of infertile patients with high-risk human papilloma virus (HPV) infection, and to analyze the clinical outcomes of these patients after assisted reproductive technology (ART). Methods: 97 infertility patients with high-risk HPV infection were selected in research group from January 2017 to December 2019, which included 33 cases with ureaplasma urealyticum (UU) infection, 64 cases with single HPV subtype infection, 39 cases with HPV16 subtype infection, 31 cases with HPV18 subtype infection, and 27 cases with other HPV subtype infection. 97 infertility patients without HPV infection were selected in control group. The T lymphocyte subsets status of the patients was compared between the two groups. The relationship between the T lymphocyte subsets status of the infertility patients with high-risk HPV infection and their pregnancy outcomes after ART was analyzed. Results: The values of CD3+, CD4+, CD4+/CD8+, and natural killer cells (NK) of the patients in the research group were significant lower than those of the patients in the control group (P<0.05), but the CD8+ value of the patients in the research group was significant higher (P<0.05). There were no statistically significant different in the values of CD3+, CD4+, CD8+, CD4+/CD8+, and NK among the patients with different high-risk HPV subtypes infection (P>0.05). The values of CD3+, CD4+, CD4+/CD8+, and NK of the patients with single high-risk HPV infection were significant higher than those of the patients with high-risk HPV and UU infection (P<0.05), but the value of CD8+ of the patients with single high-risk HPV infection was significant lower (P<0.05). 38 (39.2%) infertility patients with high-risk HPV infection had successful pregnancy. The values of CD3+, CD4+, CD4+/CD8+ and NK of the patients with successful pregnancy were significant higher than those of the patients with pregnancy failure (P<0.05), but the CD8+ value of the patients with successful pregnancy was significant lower (P<0.05). Conclusion: Infertility patients with high-risk HPV infection have immune dysfunction, and the immune dysfunction of the patients complicated UU infection is more serious, which is related to the pregnancy failure of ART.
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