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Abstract To investigate the changes and the reference value ranges of the serum free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) levels of healthy pregnant women during the first, the second, and the third trimester of pregnancy in Jiayuguan area. Methods: The clinical data of 5000 healthy pregnant women from January 2018 to December 2019 were collected retrospectively. According to the gestational weeks, these women were divided into group A (1806 women with 0-13 gestational weeks), group B (1573 women with 14-27 gestational weeks), and group C (1621 women with gestational weeks). The levels of serum FT3, FT4 and TSH of these women were detected by chemiluminescence immunoassay, which reference ranges were determined based on the 50th percentile (2.5th percentile-97.5th percentile) ［P50 (P2.5P97.5)］. Spearman test was used to analyze the correlation between the serum FT4 level of the women during the different gestational weeks and their TSH levels. Results: The serum FT3, FT4 levels of the women in group B and group C were significant lower than those of the women in group A, but the TSH level of the women in group B and group C was significant higher (P<0.05). The serum FT4 level of the women in group C was significant lower than that of the women in group B, but the TSH level of the women in group C was significant higher (P<0.05). The reference range of serum FT3 level of the women during the first, the second, and the third trimester of pregnancy were 3.80-5.36 pmol/L, 3.496.01 pmol/L, and 3.57-5.83 pmol/L, respectively. The reference range of serum FT4 level of the women during the first, the second, and the third trimester of pregnancy were11.04-22.85 pmol/L, 10.53-20.72 pmol/L, and 9.26-16.87 pmol/L, respectively. The reference range of serum TSH level of the women during the first, the second, and the third trimester of pregnancy were 0.05-4.36 mIU/L, 0.43-5.12 mIU/L, and 0.70-6.25 mIU/L, respectively. The serum FT4 level of the women during the first and the second trimester of pregnancy were negatively correlated with their serum TSH level (P<0.05), but the serum FT4 level of the women during the third trimester of pregnancy wasn’t correlated with their serum TSH level (P>0.05). Conclusion: The reference range of thyroid hormones established in this study may provide evidence for the diagnosis and treatment of thyroid diseases during pregnancy in Jiayuguan area.
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