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| Influence of desogestrel and ethinyl estradiol used for adjuvant therapy after curettage in women with missed abortion on their MMP9 and TGF-β3 mRNA levels in endometrial tissue and the effect of endometrial repair |
| Qinhuangdao Maternal and Child Health Care Hospital, Hebei Province, 066000 |
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Abstract To explore the repair effect of desogestrel and ethinyl estradiol used for adjuvant therapy of women after curettage because of missed abortion, and to study the changes of their levels of MMP9 and TGF-β3. Methods: The clinical data of 160 women after curettage because of missed abortion from January 2019 to December 2020 were collected. The postoperative complications, such as incomplete miscarriage, amenorrhea, and cervical adhesions, and the endometrial thickness, the vaginal bleeding time, and the time of menstrual recovery of the women were statistics analysed. The TGF-β3 and MMP9mRNA expression levels, and the correlation and the predictive value of which were also analyzed. Results: The rate of postoperative cervical adhesions (10.0%), the vaginal bleeding time (3.1±1.8 d), the time of menstrual recovery (26.9±2.7 d), and the endometrial thickness (2.4±0.7 mm) of the women had obviously improved after treatment. The levels of MMP-9 (0.931±0.026) and TGF-β3 (0.939±0.024) in endometrial tissue of the women had decreased significantly after treatment (all P<0.05). The levels of MMP-9 and TGF-β3 in endometrial tissue of the women were associated with their complications rate and endometrial thickness. The levels of MMP-9 and TGF-β3 combined with the complications and endometrial thickness of the women for evaluating the efficacy of postoperative treatment had certain clinical value (AUC=0.852), which sensitivity and specificity were 89.4% and 86.5%. Conclusion: Desogestrel and ethinyl estradiol used for adjuvant therapy of women after curettage because of missed abortion can significantly reduce the incidence of complicatios and fibrosis factor levels, can effectively alleviate the severity of endometrial injury after curettage, and can improve postoperative recovery.
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