To explore the relationship between the vascular grading of endometrial carcinoma by three-dimensional ultrasound of the patients and their FIGO clinicopathological stage, and the expression levels of IGF-1 and IGF-2. Methods: The basic data of 120 patients with suspected endometrial cancer from February 2018 to October 2020 were analyzed. These patients were all given three-dimensional ultrasound examinations. The pathological biopsy results were used as the gold standard to analyze the accuracy of the results by three-dimensional ultrasound. 106 patients confirmed endometrial cancer of were divided into three groups according to the vascular grading by three-dimensional ultrasound, which included group A (24 cases with grade I), group B (60 cases with grade II), and group C (22 cases with grade III). The correlation between the vascular grading of the patients and their hemodynamics, their levels of IGF-2 and IGF-1, or their FIGO clinicopathological stage was analyze. The correlation between the IGF-2 and IGF-1 expression levels of the patients and their values of RI, EDV, PI, and PSV was analyzed by Pearson method. Results: The accuracy, the specificity, and the sensitivity of three-dimensional ultrasound examination for diagnosing endometrial carcinoma were 96.7% (116/120), 100.0%, and 98.1%, respectively. As for FIGO clinical pathologic stage, the proportion of the patients with Ⅲ-Ⅳ stage in group C was the highest, the proportion of the patients with Ⅱ-Ⅲ stage in group B was the highest, and the proportion of the patients with Ⅰ-Ⅱ stage in group A was the highest. The values of RI and PI of the patients in group C were significant lower than those of the patients in group A and group B, but the values of EDV, PSV, and the IGF 1 mRNA and IGF-2 mRNA expression levels of the patients in group C were significant higher than those of the patients in group A and group B. The correlation analysis showed that, the vascular staging by three-dimensional ultrasound was negatively correlated with the values of RI and PI, but which was positively correlated with the levels of IGF-1 mRNA and IGF-2 mRNA expressions. FIGO clinical pathologic stage was positively correlated with the values of EDV and PSV. The IGF-1 mRNA and IGF-2 mRNA expression levels were negatively correlated with the RI value, but were positively correlated with the values of EDV and PSV (all P<0.05). Conclusion: The vascular grading of endometrial cancer of the patients by threedimensional ultrasound has certain correlations with their FIGO clinicopathological staging, hemodynamics, IGF-1 and IGF-2 expression levels, which have higher diagnostic values and which can provide objective evidences for treatment planning.