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| Clinical efficacy of hysteroscopic electrotomy combined with levonorgestrel intrauterine sustained release system for treating the women with endometrial polyps and its effect on their sex hormone and lipid metabolism levels |
| Naval Anqing Hospital of the Chinese People's Liberation Army, Anqing, Anhui Province, 246003 |
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Abstract To investigate the clinical efficacy of hysteroscopic electrotomy combined with levonorgestrel intrauterine prolonged release system (LNG-IUS) for treating the women with endometrial polyps, and to study its effect on the sex hormone and lipid metabolism levels of the women. Methods: From January 2018 to January 2021, 50 women with endometrial polyp were given hysteroscopic surgery for treating endometrial polyps. According to the method of random number, these women were divided into observation group and control group (25 cases in each group). The women in the observation group were also inserted LNG-IUS. All these women were followed up for two years after surgery. The levels of follicular estrogen (FSH) and estradiol (E2), the total cholesterol (CHO), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), apolipoprotein A1 (LAA1), and apolipoprotein B (LAB) of the women in the two groups were measured before surgery, 6 months and 12 months after surgery. The incidences of complications, infection, and the recurrence of endometrial polyps of the women in the two groups were analyzed. Results: The curative effect (96.0%) of the women in the observation group was significant higher than that (76.0%) of the women in the control group (P<0.05). The FSH and LH levels of the women in the two groups had decreased significantly after treatment, and which of the women in the observation group was significant lower than that of the women in the control group. The levels of CHO, TG, LDL-C, LAA1, and LAB of the women in the observation group were significant lower than those of the women in the control group, but the HDL-C level of the women in the observation group was significant higher (all P<0.05). The rates of complications (4.0%) and the recurrence (0%) of the women in the observation group were significant lower than those (20.0% and 16.0%) of the women in the control group (P<0.05). The preoperative menstrual cycle duration and menstrual pain scores of the women in the observation group had no significant different than those before operation (P>0.05), but the preoperative menstrual blood loss of the women in the observation group had increased significantly (P<0.05). Conclusion: Hysteroscopic electrotomy combined with LNG-IUS for treating the women with endometrial polyps has exact efficacy, which can improve their levels of sex hormone and lipid metabolism.
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