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| Analysis of the relationship between vaginal flora disorder and severity of PCOS, and the influencing factors of PCOS |
| The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei Province, 445000 |
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Abstract To explore the relationship between the vaginal flora disorders of women with polycystic ovary syndrome (PCOS) and their severity of PCOS, and to study the influencing factors of PCOS. Methods: 304 women with PCOS were selected from May 2017 to April 2020. And according to whether had ovulation or rare ovulation (O), the androgen (HA) level, or whether had polycystic changes of ovary (P), these women were divided into group A (72 women with O+HA+P), group B (85 women with O+HA), group C (78 women with HA+P), and group D (69 women with O+P). During the same period, 60 healthy women were selected in control group. Vaginal secretions of all the women were collected after menstruation 7 days for detected the parameters of vaginal secretions, such as pH value, flora density, and flora diversity. The relationship between the severity of the PCOS of the women and their vaginal flora imbalance was analyzed. Logistic regression analysis was used to analyze the independent factors affecting the incidence of PCOS. Results: There were no significant differences in microflora density, microflora diversity, dominant bacteria, detection rates of trichomonas and candida, and PH value of the women among the five groups (P>0.05). The proportion of cleanliness (III and Ⅳ) and the rate of maladjustment of vaginal microflora of the women had significant different among the five groups, and which of the women in group A were significant higher than of the women in the control group (P<0.05), but which of the women had no significant different among group A, B, C, and D (P>0.05). Logistic regression analysis showed that vaginal microflora disorder (OR=2.234, 95%CI: 1.301-3.838), menstrual cycle disorder (OR=2.038, 95%CI:1.069-3.884), negative mood (OR=2.770, 95%CI:2.238-3.430), and poor sleep quality (OR=2.482, 95%CI: 1.373-4.486) were the independent risk factors of PCOS (P<0.05). Conclusion: The imbalance of vaginal flora is related to the severity of PCOS. The vaginal flora disorder, menstrual cycle disorder, negative emotion, and poor sleep quality were the risk factors of PCOS, so clinical intervention based on which should be done to reduce the incidence of PCOS of the women.
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