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| Effect of clomiphene citrate combined with low-dose aspirin for improving the symptoms of infertility women with polycystic ovary syndrome and its influence on the levels of miR-224 and miR-206 expression |
| Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei Province, 445000 |
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Abstract To study the effect of clomiphene citrate combined with low-dose aspirin for improving the symptoms of infertility women with polycystic ovary syndrome (PCOS), and to study its influence on the levels of miR-224 and miR-206 expression of the women. Methods: 120 infertility women with PCOS were included as the research objects and were randomly divided into two groups by random number method from February 2017 to December 2018. The women in the two groups were treated with clomiphene citrate from the fifth day of menstruation to the day of ovulation for 3 menstrual cycles. The women in the observation group were given low-dose aspirin additionally. The treatment effect, the sex hormone levels, the follicular and endometrial changes, the ovarian blood flow situation, the serum mir-224 and miR-206 levels, and the adverse reactions rate of the women were compared between the two groups. Results: After treatment, the pregnancy rate (61.7%) and the ovulation rate (78.3%) of the women in the observation group were significant higher than those (43.3% and 61.7%) of the women in the control group (P<0.05). After treatment, the dominant follicle number, the thickness of endometrial hyperplasia, and the cervical mucus score of the women in the two groups had increased significantly, and those of the women in the observation group were significant higher than those of the women in the control group. The levels of follicle-stimulating hormone, estradiol, luteinizing hormone of the women in the two groups had decreased significantly, and those of the women in the observation group were significant lower than those of the women in the control group. The values of the maximum velocity and resistance index of ovary blood flow index of the women in the two groups had improved significantly, and the improved degree of which of the women in the observation group were significant better than those of the women in the control group. The levels of Mir-224 and Mir-206 had decreased significantly, and which of the women in the observation group were significant lower than those of the women in the control group (all P<0.05). There was no significant difference in the incidence of adverse reaction of the women between the two groups (P>0.05). Conclusion: Clomiphene citrate combined with low-dose aspirin for treating the infertility women with PCOS can decrease their sex hormone level significantly and the levels of mir-224 and miR-206, and can improve the therapeutic effect significantly with good safety.
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