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| Effect of embryo removed by salpingostomy combined with different doses of methotrexate for treating patients with ectopic pregnancy and Its influence on their levels of creatine kinase, progesterone, inhibin-A, pregnancy-associated plasma protein-A |
| Yongkang Traditional Chinese Medicine Hospital, Zhejiang Province, 321300 |
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Abstract To investigate the effect of embryo removed by salpingostomy combined with different doses of methotrexate (MTX) for treating patients with ectopic pregnancy (EP), and to study its influence on the levels of creatine kinase (CK), progesterone (P), inhibin-A and pregnancy-associated plasma protein-A (PAPP-A) of the patients. Methods: 84 patients with EP were enrolled and were randomly divided into two groups (42 cases in each group) by random envelope method from February 2016 to May 2019. The patients in control group had received low-dose MTX (25 mg) and embryo removed by laparoscopic salpingostomy, while the patients in observation group had received middle-dose MTX (50 mg) and embryo removed by laparoscopic salpingostomy. The recovery time of β-hCG level, stop time of vaginal bleeding, and fallopian tube patency rate of the patients were compared between groups. The levels of serum CK, P, inhibin-A, and PAPP-A of the patients in the two groups were recorded, and the adverse reactions rate of the patients in the two groups was analyzed. Results: The recovery time of β-hCG level (16.4±3.9d) and the stop time of vaginal bleeding (9.1±3.2d) of the patients in the observation group were significant lower than those (21.4±4.1d and 12.8±3.3d) of the patients in the control group, and the patency of the fallopian tube of the patients in the observation group was significant better than that of the patients in the control group. The levels of serum CK (61.29±10.93 U/L), P of the patients in the observation group was significant (2.93±0.62 ng/ml), inhibin-A (15.31±3.80 pg/ml), and PAPP-A (3.01±0.42 Mu/L) of the patients in the observation group were significant lower than those of the patients in the control group. The total incidence of adverse reaction (16.7%) of the patients in the observation group was significant lower than that (31.0%) of the patients in the control group (P<0.05). Conclusion: Application of embryo removed by salpingostomy combined with middle-dose MTX for treating the patients with EP can effectively promote the recovery, and improve their levels of serum CK, P, inhibin-A, and PAPP-A.
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