To analyze the effect of HEOS hysteroscopy for treating patients with intrauterine adhesions, and to study the influence factor of the curative effect. Methods: A total of 106 patients with intrauterine adhesions were included and were randomly divided into observation group and control group from January 2018 to January 2020. The patients in the control group were treated with conventional hysteroscopic surgery, and the patients in the observation group were treated with HEOS Laparoscopic surgery. The intraoperative blood loss, operation time, intraoperative complications of the patients in the two groups were analyzed. The serum progesterone (P) and estradiol (E2) levels before operation and 3 months after operation of the patients in the two groups were detected. Bultrasound was used to measurementthe endometrial thickness of the patients. The clinical efficacy of the patient in the two groups 3 months after the operation was recorded. Logistic regression model was used to analyze the factors affecting the clinical efficacy of HEOS hysteroscopy. Results: The operation time (13.2±3.5min) of the patient in the observation group was significant lower than that (22.4±4.6 min) of the patient in the control group. After treatment, the clinical efficacy (92.5%), the serum P level (40.86±4.12 nmol/L), the serum E2 level (487.98±12.05 nmol/L), and the endometrial thickness (8.87±0.83mm) of the patient in the observation group were significant higher than those (83.0%, 37.25±5.58 Nmol /L, 476.15±13.58 nmol/L, and 6.48±0.92mm) of the patient in the control group (all P<0.05). As for the patients with intrauterine adhesions, the long course of disease, wide range of intrauterine adhesions, dense nature of adhesions, placement of intrauterine device and, high grade of adhesions were the independent risk factors affecting the postoperative effect of HEOS hysteroscopy (P<0.05). Conclusion: HEOS hysteroscopy for treating the patient with intrauterine adhesions can significantly improve the clinical efficacy. It is suggested that preoperative attention should be paid to the possible factors influencing the treatment of the patient for improving the curative effect.