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| Expression of serum miR-145 level of infertility women with endometriosis, and its association with clinicopathological type and pregnancy outcomes |
| The First Central Hospital of Tianjin, Tianjin, 300070 |
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Abstract To investigate the expression of serum miR-145 level of infertility women with endometriosis (EMT), and to study its association with clinicopathological type and pregnancy outcomes of the women. Methods: 122 infertility women with EMT were selected in study group between January 2017 to December 2019, and 100 healthy women were selected in control group during the same period. The serum miR-145 expression level of the women was compared between the two groups, and was compared among the women with different clinical pathological types in the study group. The value of preoperative serum miR-145 level of the women in the study group for predicting their postoperative pregnancy outcomes was analyzed. Results: The serum miR-145 level (0.78±0.12) of the women before surgery in the study group was significant higher than that (0.56±0.09) of the women in the control group, and the serum miR-145 level of the women after surgery in the study group (0.67±0.10) was significant higher than that before surgery (all P＜0.05). In the study group, the preoperative serum miR-145 level of the women with adenomyosis was significant higher than that of the women with peritoneal type EMT or internal capsule type EMT (P＜0.05), while there was no significant difference in the level of serum miR-145 between the women with peritoneal type EMT and the women with internal capsule type EMT (P＞0.05). The intrauterine pregnancy rate (42.6%) and cumulative pregnancy rate (54.1%) of the women with high miR-145 level were significant lower than those (63.9% and 73.8%) of the women with low miR-145 level (P＜0.05). ROC curve showed that the optimal cutoff value of preoperative serum miR-145 level of the infertility women with EMT was 0.685, the area under the curve (AUC) was 0.758 (95%CI 0.670-0.847), and the sensitivity and the specificity were 70.5% and 69.2%, respectively. Conclusion: The level of serum miR-145 of infertility women with EMT increases, which is different in the women with different clinicopathological types and in the women with different pregnancy outcomes. It means the expression level of miR-145 of infertility women with EMT before surgery has some predictive value for postoperative pregnancy outcomes.
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