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| Correlation between serum pregnancy-associated plasma protein-A and β-hCG levels of pregnant women and their occurrence of gestational diabetes mellitus and adverse pregnancy outcomes |
| 1.Northwest Women's and Children's Hospital, Xi'an, Shaanxi Province, 710061; 2.Xi'an Central Hospital Affiliated to Xi'an Jiaotong University |
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Abstract To observe correlation between serum serum pregnancy-associated plasma protein-A (PAPP-A) and human chorionic gonadotropin (β-hCG) levels of pregnant women and their occurrence of gestational diabetes mellitus (GDM) and adverse pregnancy outcomes. Methods: The clinical data of 140 pregnant women with GDM and adverse pregnancy outcomes from January 2017 to January 2020 in observation group were collected retrospectively, and their type of adverse pregnancy was identified according to the pregnancy outcomes. 140 healthy primiparas with good pregnancy outcomes were selected in control group during the same period. The levels of serum PAPP-A and β-hCG of the women were compared between the two groups. Correlation analysis was performed. Results: The serum PAPP-A level of the women in the observation group was significant lower than that of the women in the control group. The serum β-HCG level of the pregnant women with threatened abortion or fetal intrauterine dysplasia in the observation group was significant higher than that of the women in the control group (P＜0.05), but the serum β-HCG level of the pregnant women with ectopic pregnancy in the observation group was significant lower than that of the women in the control group (all P＜0.05). Correlation analysis showed that serum PAPP-A level was negatively correlated with the rates of GDM, fetal intrauterine dysplasia, ectopic pregnancy, and threatened abortion, while serum β-HCG level was positively correlated with the rates of GDM, fetal intrauterine dysplasia and threatened abortion, and serum β-HCG level was negatively correlated with ectopic pregnancy rate (all P＜0.05). Conclusion: The levels of serum of PAPP-A and β-hCG are closely related to the occurrence of GDM and adverse pregnancy outcomes, which may be applied as indexes for evaluating the risk of GDM and adverse pregnancy outcomes.
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