|
|
|
| Significance of HPV E6 / E7mRNA combined with TCT examination used for population shunt of women with atypical squamous cells of unclear significance |
| Jinhua People's Hospital, Zhejiang Province, 321000 |
|
|
|
|
Abstract To evaluate the diagnostic significance of cervical human papillomavirus (HPV) E6 / E7mRNA combined with thin-layer liquid-based cytology (TCT) for population shunt of women with atypical squamous cells of unclear significance (ASCUS). Methods: 120 women who were screened for cervical cancer were selected in this study from August 2016 to August 2019, and all of them had accepted HPV E6/E7mRNA test and TCT. Based on the gold standard of colposcopy biopsy results, the diagnostic efficacy of HPV E6/E7mRNA alone, TCT alone, or HPV E6/E7mRNA combined with TCT for ASCUS was evaluated. Results: Among the 120 women after cervical cancer screening, 52 women were diagnosed as ASCUS, and there were 68 women without tumor cells (NILM). Based on the gold standard of colposcopy biopsy results, the diagnostic sensitivity (94.2%), the specificity (88.2%), the accuracy (90.8%), the positive predictive value (86.0%), and the negative predictive value (95.2%) for diagnosing ASCUS by E6/E7mRNA combined with TCT were significant higher than those by E6/E7mRNA alone or TCT alone (P＜0.05). Conclusion: Both HPV E6/E7mRNA and TCT have certain diagnostic significance in the population shunt of the women with ASCUS, but the combined diagnostic efficiency of HPV E6/E7mRNA and TCT is higher, which can provide more reference for clinical diagnosis and treatment, and can improve the accuracy of screening cervical cancer early.
|
|
|
|
|
|
|
|
|
