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| Value of HPV E6/E7mRNA detection for shunting management and predicting disease progression of patients with ASCUS |
| Yuyao People's Hospital, Zhejiang Province, 315400 |
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Abstract To analyze the value of E6/E7 mRNA of HPV detection for predicting disease progression of patients with atypical squamous cells of undetermined significanc (ASCUS) in 24 months, and to provide evidence for shunting management of patients. Methods: 476 patients with ASCUS by TCT were selected as the study objects from January 2016 to December 2017. The difference of the positive detection rates of patients with different cervical biopsy results were compared between E6/E7 mRNA of HPV detection and HPV DNA detection, and the efficacy of E6/E7 mRNA of HPV detection and HPV DNA detection for predicting patients with cervical biopsy pathology≥HSIL in 12 and 24 months followed up was analyzed. Results: The positive rate of HPV DNA detection for patients with chronic inflammation and LSIL was significant higher than that of E6/E7 mRNA of HPV detection (P<0.05), and there was no statistical significant difference in the positive rate of HSIL and cervical cancer between HPV DNA detection and E6/E7 mRNA of HPV detection (P>0.05). The specificity and positive predictive value of E6/E7 mRNA of HPV detection for patients with HSIL or above lesions were 40.5% and 23.7%, which were significant higher than those (19.0% and 18.4%) of HPV DNA detection (P<0.001). There were no significant difference in the sensitivity and the negative predictive value between E6/E7 mRNA of HPV detection and HPV DNA detection (P>0.05). Both the primary E6/E7 mRNA of HPV detection and HPV DNA detection had certain predictive efficacy for the patients with cervical biopsy pathology≥HSIL in 12 months and 24 months followed up (P<0.001), the predictive efficacy for the patients in the 12th month after diagnosed was significant better than that in the 24th month, and the predictive efficacy by E6/E7 mRNA of HPV detection E6/E7 mRNA was superior to that by HPV DNA detection. Conclusion: The E6/E7 mRNA of HPV detection can better distinguish the high-grade lesions of patients with ASCUS, which’s prediction value for patients with disease progression within 12 months after diagnosed is superior to that by HPV DNA detection.
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