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| Relationship between the levels of HbAlc and inhibin, and intestinal flora status of the pregnant women with gestational diabetes mellitus and their adverse pregnancy outcomes |
| The Third People's Hospital of Yibin, Sichuan Province, 644000 |
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Abstract To investigate the relationship between the levels of HbAlc and inhibin, and intestinal flora status of the pregnant women with gestational diabetes mellitus (GDM) and their adverse pregnancy outcomes. Method: 100 pregnant women with GDM were selected in study group and 110 pregnant women without GDM were selected in control group from April 2016 to March 2019. The changes of the levels of HbAlc and inhibin, and intestinal flora status of the women in the two groups were observed. And the relationship between the levels of HbAlc andinhibin, and intestinal flora status of the women in the study group and their adverse pregnancy outcomes were observed. Results: The level of HBALC (7.14±0.25) of the women in the study group was significant higher than that of the women in the control group, and the levels of statin A (242.32± 96.35pg /ml) and statin B (607.73± 101.65pg /ml) of the women in the study group were significant lower than those of the women in the control group. The percentages of firmicutes (69.9±12.4%) and actinomycetes (3.1±1.1%) of the women in the study group were significant higher than those of the women in the control group, but the percentages of bacteroidetes (20.4±6.0%) and proteobacteria (4.7±2.1%) of the women in the study group were significant lower than those of the women in the control group (P＜0.05). The incidences of preterm delivery, hyperhydramnios, macrosomia, fetal distress, and neonatal hypoglycemia in the study group were significant higher than those in the control group (P＜0.05). There was no difference in the incidence of premature rupture of membranes of the women between the two groups (P＞0.05). In the study group, the incidences of preterm delivery, hyperhydramnios, macrosomia, fetal distress, premature rupture of membranes, neonatal hypoglycemia, the HBALC level, and the proportion of intestinal firmicutes of the women with adverse pregnancy outcomes were significant higher than those of the women with normal pregnancy outcomes. The levels of tatin A and B, and the proportion of intestinal bacteroidetes of the women with adverse pregnancy outcomes were significant lower than those of the women with normal pregnancy outcomes (all P＜0.05). Conclusion: The levels of serum HbAlc and inhibin, and intestinal flora status of the pregnant women with GDM are abnormal, which are closely related to their adverse pregnancy outcomes.
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