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Abstract To explore the current status of high-risk human papillomavirus (HPV) infection of women from Haikou area, and to analyze the related risk factors of high-risk HPV infection. Methods: The HPV testing results and genotyping data of 26245 women from Haikou area who had participated in HPV screening from January 2018 to December 2019 were collected. The distribution characteristics of high-risk HPV infection were analyzed. Structured questionnaire survey was used to obtain the relevant information of these women, and multi-factor regression analysis was used to analyze the risk factors related to high-risk HPV infection. Results: Among the 26,245 women, the rate of high-risk HPV infection was 9.2% (2401 women). In the women with high-risk HPV infection, there were 83.1% women with single infection and 17.0% women with mixed infection. In the women with single infection, the infected percentage of HPV-16 type (19.9%), HPV18 type (15.4%), and HPV-52 type (13.5%) were the most common of high-risk HPV infections. In the women with mixed infection, the infected percentage of HPV-16 type combined with HPV-52 type (26.0%) or HPV-58 type（24.3%）were the most common. The two age peaks of women with high-risk HPV infection were 20-29 years old (14.7%) and 50-59 years old (13.8%). The infection rate of high-risk HPV of the women with >60 years old was significant higher than that of the women with <20 years old, that of the women with 30-39 years old, or that of the women with 40-49 years old (P＜0.05). There were significant differences in smoking history, number of sexual partners, contraception used, and vaginal inflammation situation between the women with and without HPV infection (P＜0.05), but there were no differences in occupation, education level, and fertility history between the women with and without HPV infection (P＞0.05). Unconditional Logistic regression analysis showed that the number of sexual partners, oral contraceptive, and history of vaginal inflammation were the risk factors of high-risk HPV infection (P＜0.05). Conclusion: The infection rate of high-risk HPV of women in Haikou area is high, and the single infected by HPV16 type alone or HPV-58 type alone, and the mixed infected by HPV-16 type combined with HPV-52 or HPV-58 type are the most. 20-29 years old and 50-59 years old are the two age peaks of the women with high risk HPV infection. The number of sexual partners, oral contraceptives, and history of vaginal inflammation are the risk factors of high-risk HPV infection.
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