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| Diagnostic value of uric acid level for preeclampsia: a meta-analysis |
| The First Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, 030001 |
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Abstract To evaluate the diagnostic value of uric acid level for preeclampsia. Methods: The relevant literatures in the databases up to July 2020, such as Chinese national knowledge infrastructure (CNKI), Wanfang, VIP, China biomedical literature database, PubMed, Embase, Cochrane Library, Clinical registry and systematically, were searched. According to the inclusion and exclusion criteria, the original literatures were screened, the quality of the literatures was evaluated, and the data were extracted from the literatures. Results: There were 10 literatures included in this meta-analysis. The pooled sensitivity, specificity, positive and negative likelihood ratio, and diagnostic odds ratio were 0.72 (95%CI: 0.69-0.74), 0.61(95%CI: 0.60-0.62), 3.28 (95%CI: 1.98-5.48), 0.33(95%CI: 0.21-0.51), and 10.36 (95%CI: 5.10-21.05), respectively. Area under the curve was 0.8380. Meta-regression analysis showed that sample size and cutoff value were the main sources of heterogeneity. There was no statistical significance for the evaluation of publication bias by Deek funnel plot. Fagan graphs showed that the pre-test probability was 50%, and the post-test probability was 94%. Conclusion: Uric acid level has higher diagnostic efficiency for preeclampsia, but its specificity is slightly poor, which should be further confirmed by more prospective researches with large samples.
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ZHOU Qing, LIU Shuaimei, LIN Ning, ZHANG Ruijin, LI Menglan, Feng Jie, HUANG Lili, WU Yulin, SHI Hui. Meta-analysis of the correlation between the glutathione S-transferase M1 gene polymorphism of Asian women and their cervical cancer susceptibility[J]. 中国计划生育学杂志, 2024, 32(8): 1720-. |
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