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| Meta-analysis of the correlation between the glutathione S-transferase M1 gene polymorphism of Asian women and their cervical cancer susceptibility |
| Jiangsu Health Development Research Center, National Health and Family Planning Commission Contraceptives Adverse Reaction Surveillance Center, Jiangsu Provincial Medical Key Laboratory of Fertility Protection and Health Technology Assessment, Nanjing, Jiangsu Province, 210036 |
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Abstract To explore the correlation between the glutathione S-transferase M1(GSTM1) gene polymorphism of women in Asia and their cervical cancer susceptibility. Methods: The articles about the correlation between GSTM1 gene polymorphism of women in Asia and their cervical cancer susceptibility were searched in Chinese and English databases, such as CNKI, Wanfang, Pubmed, and so on. The retrieval time of the database was from the establishment of the database to May 2024. The odds ratio(OR) and its 95% confidence interval(CI) of the correlation were calculated by Stata11.0 software. Results: A total of 19 case-control studies were included, including 2324 women with cervical cancer in the case group and 2611 women without cervical cancer in the control group. Metaanalysis results showed that the homozygous deletion of GSTM1 genotype of the Asian women was significantly associated with their cervical cancer susceptibility(OR=1.74, 95%CI 1.41-2.14). The subgroup analysis showed that the homozygous deletion of GSTM1 genotype of the women in east Asian(OR=1.54, 95%CI 1.21-1.97), of the women in central Asian(OR=8.32, 95%CI 2.84-24.36), of the women in south Asian(OR=2.11, 95%CI 1.48-3.02), of the women in China(OR=2.03, 95%CI 1.46-2.82), of the women in Indian(OR=1.89, 95%CI 1.39-2.57), of the women in Kazakhstan(OR=8.32, 95%CI 2.84-24.36), or of the women in Pakistan populations(OR=5.52, 95%CI 2.34-13.07) was significantly associated with their cervical cancer susceptibility. Conclusion: The homozygous deletion of GSTM1 genotype of the Asian women may increase the risk of their cervical cancer occurrence.
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