To investigate the expression and significance of adipogenic differentiation-related proteins (ADRP), reductive nicotinamide adenine dinucleotide (NADH) dehydrogenase, heat shock protein 70 (HSP70) in placental tissue of pregnant women with pregnancy induced hypertension (PIH). Methods: 152 pregnant women with PIH were selected in study group from February 2019 to February 2020, and 110 healthy pregnant women were selected in control group. The expressions of ADRP, NADH, and HSP70 in placental tissue of these women were detected by real-time PCR and PCR, and their relevant to the disease severity, clinical characteristics, and pregnancy outcomes was analyzed. Results: The expression levels of ADRP, NADH and HSP70 mRNA in placental tissues of the women in the study group were significant higher than those of the women in the control group, and the expression levels of them had increased with the aggravation of PIH (P<0.05). The expressions of ADRP, NADH and HSP70 were not related to the age, the body mass index, and gravidity and parity of the women with PIH (P>0.05), but were related to their family history of preeclampsia, family history of hypertension, and urinary protein level (P<0.05). In the study group, the expression levels of ADRP, NADH, and HSP70 mRNA of the women with adverse pregnancy outcomes were significant higher than those women with normal pregnancy outcomes (P<0.05). The levels of ADRP, NADH and HSP70 were positively correlated (P<0.05). Conclusion: The expressions of ADRP, NADH, and HSP70 in placental tissue of the women with PIH are high, which are closely related to the severity of PIH and the pregnancy outcomes. The change of PIH can be screened and evaluated early, and the pregnancy outcomes can be predicted based on the changes of the levels of ADRP, NADH, and HSP70 in clinical practice.