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| Analysis of the efficacy of high-dose THR for treatment of GDM complicated with hypothyroidism and its influence on their fat metabolism and pregnancy outcomes |
| The Second Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830000 |
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Abstract To explore the effect of high-dose THR for treating women with gestational diabetes mellitus (GDM) and hypothyroidism, and to study its influence on their fat metabolism and pregnancy outcomes. Methods: 100 singleton pregnant women with GDM and hypothyroidism were selected and were divided into two groups (50 cases in each group) from June 2019 to February 2020. The women in the research group were given conventional treatment combined with high-dose THR, and the women in the control group were given conventional treatment combined with low-dose THR. The clinical efficacy of the women was compared between the two groups. Results: After 4 weeks of treatment, the total clinical effective rate (90.0%) of the women in the research group was significant higher than that (74.0%) of the women in the control group. The improved levels of serum free thyroxine (12.9±3.8pmol/L), free triiodothyrogenine (4.5±0.8pmol/L), and thyrotropin (6.6±1.2mU /L) of the women in the research group were significant more than those of the women in the control group. The improved levels of fasting blood glucose and lipid metabolism of the women in the research group were significant more than those of the women in the control group. The incidence of adverse pregnancy outcomes (16.0%) of the women in the research group was significant lower than that (34.0%) of the women in the control group (P<0.05). Conclusion: High-dose THR for treating women with GDM and hypothyroidism is more effective, which can not only improve thyroid function and lipid metabolism, but also effectively reduce the incidence of adverse pregnancy outcomes. However, follow-up, detection and adjustment should be made according to the tolerance of these women for avoiding serious consequences.
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