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Abstract To analyze the risk factors of the severe preeclampsia and the adverse pregnancy outcomes of pregnant women. Methods: The clinical data of the pregnant women who were treated in hospital from January 1, 2022 to March 31, 2023 were analyzed retrospectively. 88 pregnant women with severe preeclampsia based on their medical records were randomly selected from these women in the study group, and 172 women without severe preeclampsia were selected in control group. The general clinical data, the rate of the complications, and the levels of laboratory indicators, such as hematocrit, platelet (PLT), hemoglobin (HGB), albumin (ALB), total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL) and homocysteine (HCY), of the women were compared between the two groups. Logistic regression model was used to analyze the risk factors of the severe preeclampsia. The adverse pregnancy outcomes and the adverse perinatal outcomes were compared between the two groups. Results: The incidences of the systolic blood pressure, diastolic blood pressure, gestational diabetes mellitus, ICP, impaired liver function, pregnancy combined with hypothyroidism and antiphospholipid syndrome, and the levels of hematocrit, PLT, HGB, ALB, TC, LDL and HCY of the women in the study group were significantly higher than those of the women in the control group. The HDL level of the women in the study group was significantly lower than that of the women in the control group (all P<0.05). Logistic regression analysis showed that the gestational diabetes mellitus, the impaired liver function, the pregnancy complicated with hypothyroidism, the antiphospholipid syndrome, the increased hematocrit, LDL and HCY and the decreased HDL of the pregnant women were the independent risk factors of their severe PE occurrence (P<0.05). The incidences of the placental abruption, hypoproteinemia, preterm birth, intrauterine fetal death, intrauterine growth retardation, fetal distress and fetal asphyxia of the women in the study group were significantly higher than those of the women in the control group (all P<0.05). Conclusion: It is necessary to strengthen the monitoring of the pregnant women with the high-risk factors of the severe PE in clinical practice, so as to reduce the occurrence of the adverse maternal and infant outcomes and improve the prognosis of the mothers and infants.
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