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| Influence of preoperative goserelin used combined with laparoscopic surgery on uterine blood flow resistance, fibroid volume and hemoglobin level of patients with uterine fibroids |
| 1. Maternal and Child Health Care and Family Planning Service Center, Liangshan Prefecture, Sichuan Province, 615000; 2. Chengdu Women's and Children's Central Hospital |
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Abstract To explore the influence of preoperative goserelin used combined with laparoscopic surgery on uterine blood flow resistance, fibroid volume and hemoglobin (Hb) level of patients with uterine fibroids. Methods: Clinical data of 48 uterine fibroids patients with uterine volume ≥14 gestational weeks who had treated by goserelin combined with laparoscopic surgery in observation group and 42 uterine fibroids patients with uterine volume of 10-12 gestational weeks who had treated by laparoscopic surgery in control group were collected retrospectively. The uterine volume, uterine fibroid volume, Hb level, and uterine blood flow resistance index, such as uterine artery resistance index (RI), main fibroid vascular resistance index (RI)of patients were compared before and after treatment between the two groups. And the perioperative indexes, the rate of postoperative complications, and the rate of adverse drug reactions were also compared between the two groups. Results: The uterine volume and uterine fibroid volume of patients in the observation group before treatment were significant lower than those of patients before treatment (P＜0.05), while the Hb level of patients in the observation group was significant higher (P＜0.05). There were no significant different in the uterine volume, uterine fibroid volume, and Hb level of patients before treatment between the two groups (P＞0.05). The values of uterine artery RI and fibroid vascular RI of patients in the observation group had increased significantly after treatment (P＜0.05), and were significant higher than those of patients in the control group before treatment, but the operative time, intraoperative blood loss, postoperative hospital stay, and total incidence rate of postoperative complications of patients in the observation group were significant lower (P＜0.05). In the observation group, there were 81.3% patients with amenorrhea, 47.9% patients with hot flashes, 25.0% patients with insomnia, and 10.4% patients with limb pain after treatment. Conclusion: Preoperative goserelin used can promote the successful completion of laparoscopic surgery of patients with uterine fibroids, and can reduce postoperative complications, which has significance for promoting postoperative rehabilitation of patients.
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