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Abstract To explore the value of the detection of peripheral serum α1-antitrypsin (α1-AT) level combined with the chorionic gonadotropin level for predicting the pregnancy outcomes of women with threatened abortion. Methods: The data of 112 women with threatened abortion were collected retrospectively from June 2017 to December 2018. According to the pregnancy outcomes, these women were divided into group A (56 women with abortion) and group B (56 women with continues pregnancy). During the same time, 56 normal pregnant women were selected in group C. The levels of serum α1-AT, β-hCG, and progesterone (P) of women in the three groups were detected. ROC curve analysis was used to evaluate the predictive value of α1-AT and β-hCG levels for pregnancy outcomes of women with threatened abortion. Results: The levels of P, β-hCG, and α1-AT of women in group A were significant lower than those of women in group B and C (P＜0.05), but which had no significant different between group B and group C (P＞0.05). ROC curve analysis showed that serum P, β-hCG and α1-AT levels of women in the group A had predictive value for threatened abortion. The accuracy of α1-AT level and β-hCG level for predicting abortion were 70.3% and 73.3%, which were significant higher than that (46.4%) of P level. 48 h and 72 h After treatment, the levels of P, β-hCG and α1-AT of women in group A were also significant lower than those of women in group B (P＜0.05). Conclusion: The combined detection of serumα1-AT level and β-hCG level can help to evaluate the prognosis of women with threatened abortion, which has important guiding significance for early preventing threatened abortion.
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