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Abstract To investigate the effect of leuprolide acetate (LA) of super-long regimen in vitro fertilization-embryo transfer (IVF-ET) for treating infertility women with adenomyosis and ovarian endometriosis. Methods: Clinical data of 197 infertility women with adenomyosis and ovarian endometriosis treated by IVF-ET from February 2015 to June 2018 were collected retrospectively. According to the different ovulation promotion schemes, they were divided into group A (routine long ovulation promotion scheme, 48 cases), group B (super long ovulation promotion scheme, 82 cases), and group C (LA combined with super long ovulation promotion scheme, 67 cases). The pregnancy outcomes of women were compared among the three groups. Result: There was no significant difference in the level of progesterone (P) on the human chorionic gonadotropin (HCG) injection day of women between group A and group B (P>0.05), and the initial total dosage of gonadotropin (Gn), Gn used time, total Gn dosage of women in group A were significant higher than those of women in group B, but the levels of E2 and LH on the HCG injection day, and endometrial thickness (EDM) of women in group A were significant lower (P<0.05). There were no significant different in the levels of P, E2, and LH on the HCG injection day, Gn used time, total Gn dosage, and EDM of women between group B and group C (P>0.05). There was no significant difference in the level of P on the HCG injection day of women between group A and group C (P>0.05), the initial total dosage of Gn, and total Gn dosage of women in group C were significant higher than those of women in group A, but the levels of E2 and LH on the HCG injection day, and EDM of women in group C were significant lower (P<0.05).There were no significant different in the number of eggs obtained, MII eggs number, numbers of 2PN and 2PN cleavage, available embryos number, high-quality embryos number, clinical pregnancy rate, embryo implantation rate, live birth rate, cleavage rate, 2PN cleavage rate, fertilization rate, early abortion rate, birth defect rate, low birth weight infant rate, moderate-severe ovarian hyperstimulation syndrome (OHSS) rate, and ectopic pregnancy rate of women between group A and group B (P>0.05). There were no significant different in the number of eggs obtained, MII eggs number, fertility rate, cleavage rate, available embryos, high quality embryos, clinical pregnancy rate, live birth rate, 2PN number, 2PN cleavage number, 2PN cleavage rate, early abortion rate, birth defect rate, low birth weight infant rate, and ectopic pregnancy rate of women between group B and group C (P>0.05), the embryo implantation rate than that of women in group B, but moderate-severe OHSS rate of women in group C was significant lower than that of women in group B. Conclusion: Conventional ultra-long scheme and LA ultra-long ovulation induction scheme for treating women with adenomyosis or moderate-severe endometriosis undergoing in IVF-ET were both more effective than that of conventional long-long scheme, but the application of LA ultra-long ovulation induction scheme for early follicular stage maybe accord with the requirement of inhibiting endogenous sex hormone levels of these women, so that women could obtain higher embryo implantation rate, infant holding rate and better pregnancy outcomes.
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