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Abstract To investigate the curative effect of etonogestrel implant for relieving the clinical symptoms of women with endometriosis and adenomyosis．Methods: 44 women with endometriosis and 56 women with adenomyosis who had implanted etonogestrel implant from May 2016 to October 2017 were enrolled in this study. The changes of dysmenorrhea, menstrual volume and so on of women before and 1, 6, 12, 24 months after etonogestrel implant used were observed．Results: After etonogestrel implant used, VAS scores of dysmenorrhea of women had decreased from 6.4±2.4 before implanted to 0.6±0.4, 0.4±0.9, or 0.2±0.7 in 6, 12, or 24 months after implanted. The incidence of amenorrhea of menstruation of women in 6, 12 and 24 months after implanted were 54.7%, 57.5%, or 58.1%, respectively, which had significant different from that before implanted (P＜0.05). The main side effects included spotting bleeding (24%), amenorrhea or menstruation (58.1%), weight gain (19.0%), and acne (13.0%), etc. Conclusion: Etonogestrel implant is suit for women with endometriosis and adenomyosis. Changes in bleeding patterns, such as amenorrhea or oligomenorrhea, irregular and/or spotting, were the most common side effects of etonogestrel implants, and were also the main causes of discontinuation.
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