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| Curative efficacy of low-dose aspirin combined with labetalol for treating women with pregnancy induced hypertension disease and its effects on serum sLOX-1 and sRAGE levels |
| Gansu Maternal and Child Health Care Hospital，Lanzhou，Gansu Province，730050 |
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Abstract To explore the curative efficacy of low-dose aspirin combined with labetalol for treating women with pregnancy induced hypertension disease, and to study its influence on the levels of serum soluble lectin-like oxidized low density lipoprotein receptor-1(sLOX-1) and soluble receptors for advanced glycation end products(sRAGE). Methods: 115 pregnant women with pregnancy induced hypertension disease were selected and were divided into 60 cases in the observation group and 55 cases in the control group by the random number table from January 2016 to October 2018. The women in the control group were treated with labetalol, while the women in the observation group were treated with labetalol combined with low-dose aspirin. The changes of the values of blood pressure, 24-hour urinary protein, uterine artery hemodynamics, and serum sLOX-1 and sRAGE levels of women before and on the 7th day after treatment, and the adverse pregnancy outcomes and adverse reactions of women were compared between the two groups. Results: On the 7th day after treatment, the values of systolic blood pressure (SBP), diastolic blood pressure (DBP), urine protein at 24h, uterine artery pulse index (PI), resistance index (RI), and ratio of systolic and end-diastolic maximum blood flow velocity (S/D) of women in the observation group were all significant lower than those of women in the control group. The serum SLOx-1 level of women in the observation group was 167.46 ±19.40 g/ml, which was significant lower than that of women in the control group, but the serum sRAGE level of women in the observation group was 302.46±34.57 ng/L, which was significant higher than that (181.13±21.19 g/ml) of women in the control group. The incidences of cesarean section, premature delivery, and fetal distress of women in the observation group were significant lower than those of women in the control group (all P＜0.05). The incidence of postpartum hemorrhage (8.3%), neonatal asphyxia, death, and total adverse reactions (8.3%) of women in the observation group had no significant different from those of women in the control group (P＞0.05). Conclusion: Low-dose aspirin combined with labetalol for treating women with pregnancy induced hypertension disease had good curative effect, which can effectively regulate serum sLOX-1 and sRAGE level, and uterine artery blood flow value, can improve maternal and infant outcomes, and do not increase adverse drug reactions it's worthy for popularizing.
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