To investigate the expression features of serum high-density lipoprotein (HDL) of pregnant women with gestational diabetes mellitus (GDM) and pregnancy-induced hypertension syndrome, and to study its predictive value for pregnancy outcomes. Methods: In this study, 95 pregnant women with GDM and pregnancy-induced hypertension syndrome were selected in observation group from 2014 to 2016, and 100 healthy pregnant women were selected in control group. The fasting blood glucose, OGTT, high-density lipoprotein (HDL) level, and blood pressure of the women in the two groups were measured. And the relationship between serum HDL expression of the women in the observation group and their pregnancy outcomes was analyzed. Results: The fasting glucose level of women in the 28th gestational weeks in the observation group was 5.64±0.79 mmol/L, which was significant higher than that (4.46±0.50 mmol/L) of women in the control group. The values of systolic and diastolic blood pressure of women in the observation group were 156.68±13.94 mmHg and 7.66±9.07 mmHg, which were significant higher than those of women in the control group. The serum HDL level of women in the observation group was 1.36±0.29 mmol/L, which was significant lower than that (1.80±0.33 mmol/L) of women in the control group. The blood glucose level 1 hour and 2 hours after dinner, and the levels of low density lipoprotein (LDL), triglyceride and cholesterol women in the observation group were significant higher than those of women in the control group. The proportion of vaginal delivery of women with low HDL level was 51%, which was significant lower than that of women with normal HDL level. The incidence of postpartum hemorrhage of women with lowr HDL level 8.1%, which was significant higher than that of women with normal HDL level (P<0.05). There were no significant different in the incidences of vaginal midwifery, cesarean section, neonatal asphyxia, and stillbirth between the women with low HDL level and the women with normal HDL level. The multivariate regression analysis showed that the abnormal HDL level decreased, fasting blood glucose level, LDL level and abnormal systolic blood pressure increased of women were associated with their adverse pregnancy outcomes. Conclusion: The HDL level of pregnant women with GDM and pregnancy-induced hypertension syndrome is significantly has decreased, which is related to the the proportion of normal vaginal delivery and postpartum hemorrhage, so it is should be paid more attention to in the clinical practice.