To explore the influence of high-focus ultrasound (HIFU) and uterine artery embolization (UAE) for adjuvant treating patients with cesarean scar pregnancy (CSP) on their pregnancy after operation. Methods: 122 patients with CSP were divided into two groups according to different treatment methods from April 2016 to June 2018. 48 patients in group A were treated with UAE, and 74 patients in group B were treated with HIFU. The situation of patients during operation was compared between the two groups. Visual Analogue Scoring (VAS) was used for evaluating the degree of pain, fever, nausea and vomiting of patients in the two groups. All patients were followed up in outpatient at different time after operation. The menstrual volume, the serum human chorionic gonadotropin (hCG) level, and the rates of amenorrhea and pregnancy again of patients compared between the two group. Results: The hospitalization expenses of the patients in group B were significant lower than that of the patients in group A (P<0.05). There were no difference in operation time, intraoperative blood loss, duration of postoperative vaginal bleeding, and postoperative hospital stay of the patients between the two groups (P>0.05). The VAS, the incidence of fever, the rate nausea and vomiting of the patients in group B were 3.1±0.2 points, 4.1%, and 8.1%, which were significant less than those of the patients in group A (P<0.05). The proportion of menstrual volume reduction of the patients in group B3 months and 6 months after surgery was significant lower than that of the patients in group A (P<0.05). There were no significant difference in the rate of serum hCG turned to negative within 1 month and 3 months after surgery and the proportion of amenorrhea within 1 year after surgery between the two groups (P>0.05). The proportion of pregnancy again of the patients in group B after surgery was 43.2%, which was significant higher than that (18.8%) of the patients in group A (P<0.05). Conclusion: HIFU is an effective treatment for CSP, which can increase the rate of pregnancy again within 1 year after operation, and has high safety.