To investigate the effect of laparoscopy and hysteroscopy combined with gonadotropin releasing hormone analogue (GnRH a) for treating infertility women with endometriosis on their levels of serum sex hormones, 5 lipoxygenase (5 LOX), and lipoxin A4 (LX A4). Methods: 55 infertility women with endometriosis who had undergone laparoscopy combined with hysteroscopy were enrolled in this study, and were divided into two groups according to willingness of the women from June 2017 to December 2018. 25 women in the control group had received medroxyprogesterone acetate tablets, while 30 women in the observation group had received GnRH a treatment. The clinical efficacy, the levels of serum sex hormones, 5 LOX, and LX A4, and visual analogue scale (VAS) scores of women were compared between the two groups. Results: The total recurrence rate of women in the observation group within 1 year after surgery was 3.3%, which was significant lower than that (28.0%) of women in the control group. The cumulative clinical pregnancy rate within 1 year and 2 years after surgery were 63.3% and 76.7%, which were significant higher than those (28.0% and 48.0%) of women in the control group (all P<0.05). The postoperative fertility rate of women in the two groups were 6.03% and 2.26%, and the odd ratio of them was 2.67. After operation, the levels of E2, LH and FSH of women in both groups had decreased significantly, which of women in the observation group were significant lower than those of women in the control group, meanwhile, the levels of LXA4 and 5 LOX of women in both groups had increased significantly, which of women in the observation group were significant higher than those of women in the control group (P<0.05). The scores of sexual intercourse pain, chronic pelvic pain, and dysmenorrhea of women in the observation group were significant lower than those of women in the control group (P<0.05). Conclusion: After operation, GnRH a can effectively increase the expression levels of 5 LOX and LX A4 of infertility women with endometriosis, and can regulate their level of hormones, thereby GnRH a can reduce the postoperative recurrence rate and increase the pregnancy rate.