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| The value of fetal intracranial hyaline layer by ultrasonography combined with serum AFP and freeβ-hCG levels detection of pregnant women for diagnosing fetal neural tube malformation |
| Puyang People's Hospital, Henan Province, 457000 |
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Abstract To investigate the value of fetal intracranial hyaline layer by ultrasonography combined with serum alpha fetoprotein (AFP) and freeβsubunit of human chorionic gonadotropin (fβ-hCG) levels detection of pregnant women for diagnosing fetal neural tube malformation. Methods: From February 2017 to April 2018, 52 pregnant women with fetal neural tube malformations were selected in study group, and 222 normal pregnant women were included in control group. The levels of serum AFP and fβ-hCG were compared between the two groups. Based on the results of fetal follow-up and autopsy as the gold standard, the value of fetal intracranial hyaline layer by ultrasonography combined with serum AFP and fβ-hCG levels detection for diagnosing fetal neural tube malformation were analyzed. Results: The MoM values of serum AFP and fβ-hCG levels in the study group were significant higher than those in the control group (P<0.05). The sensitivity of fetal intracranial hyaline layer by ultrasonography combined with serum AFP and levels for diagnosing fetal neural tube malformation was 98.1%, which was siginificant higher than that (78.9%) of serum AFP level or that (75.0%) of serum fβ-hCG level. The specificity of diagnosis of combination fetal intracranial hyaline layer by ultrasonography and levels of serum AFP and fβ-hCG was 97.8%, which was siginificant higher than that (87.8%) of fetal intracranial hyaline layer by ultrasonography only, that (78.4%) of AFP level only, or that (75.7%) of serum freeβ-hCG level only. And the accuracy of diagnosis of combination fetal intracranial hyaline layer by ultrasonography and levels of serum AFP and fβ-hCG was 97.8%, which was siginificant higher than that (88.7%) of fetal intracranial hyaline layer by ultrasonography, that (78.5%) of AFP level, or that (75.6%) of serum fβ-hCG level. Conclusion: The fetal intracranial hyaline layer by ultrasonography examination, the serum AFP level, or fβ-hCG level detection all have certain values for diagnosing fetal neural tube malformation, but combination diagnosis of them can effectively improve the diagnosis efficiency.
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