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| Effect of insulin aspart injection combined with exercise therapy for treating pregnant women with GDM and its influence on hemodynamic parameters of fetal umbilical and renal arteries |
| Qinghai Red Cross Hospital, Xi’ning, Qinghai Province, 810000 |
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Abstract Objective: To analyze the clinical efficacy of insulin aspart injection combined with exercise therapy for treating pregnant women with gestational diabetes mellitus (GDM), and to study its influence on hemodynamic parameters of fetal umbilical cord and renal artery. Methods: A total of 116 pregnant women with GDM were randomly divided into two groups from January 2017 to January 2019. 58 patients in the control group were treated by metformin combined with exercise therapy until delivery, and 58 patients in the experimental group were treated by insulin aspart injection combined with exercise therapy until delivery. The clinical efficacy, blood glucose indexes, umbilical and renal artery hemodynamics indicators, and rate of adverse pregnancy outcomes of women were compared between the two groups. Results: The total clinical effective rate of women in the experimental group was 96.6%, which was significant higher than that (75.9%) of women in the control group. The 2hPG and FPG levels and the values of umbilical and renal artery RI and S/D of women in the experimental group were significant lower than those of women in the control group. The incidence of adverse pregnancy outcomes of women in the experimental group was 3.5%, which was significant lower than that (25.9%) of women in the control group (all P<0.05). Conclusion: Insulin aspart injection combined with exercise therapy can effectively reduce blood glucose level of pregnant women with GDM, and can improve their fetal kidney and umbilical artery RI, S/D values, so it can improve the pregnancy outcomes.
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