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| Analysis of candidate pathogenic genes of endometriosis using GEO Database |
| 1.Graduate School of Peking Union Medical College, Beijing, 100730; 2.National Research Institute for Family Planning |
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Abstract Objective: To explore the candidate pathogenic genes of endometriosis shared by proliferative and secretory phase during menstrual cycle. Methods: Data of 18 patients with endometriosis on GSE7305 and GSE25628 were downloaded to screen differential expressed genes (DEGs) through comparing gene expression of eutopic endometrium and corresponding ectopic endometrium. Then gene 0ntology and KEGG (Kyoto Encyclopedia of genes and genomes) were used to do bioinformatic analysis, and protein interaction network was built through String 11.0. The hub clusters were screened through Cytoscape MCODE, and advanced GO analysis was done through BiNGO. Results: There were 96 DEGs through comparing eutopic endometrium and ectopic endometrium. GO analysis showed DEGs were mainly enriched in pathway of complement activation. The results showed that CLU might be involved in the occurrence and development of endometriosis via pathway of complement activation. Conclusion: CLU gene may participate in the development of endometriosis through regulating complement activation.
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