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| The influence of early syphilis diagnose and intervention of pegnant women on their pregnancy outcomes and neonatal health |
| Anqing Hospital of People's Liberation Army Navy, Anhui Province,246003 |
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Abstract Objective: To investigate the influence of early syphilis diagnose and intervention of pregnant women on their pregnancy outcomes and neonatal health. Methods: The clinical data of 154 pregnant women with syphilis from August 2017 to June 2018 were analyzed retrospectively, in which, 49 women in group A were given treatment of syphilis during the first trimester pregnancy, 43 women in group B were given treatment of syphilis during the third trimester pregnancy, and 62 women in group C were not given treatment of syphilis. The pregnancy outcomes and newborn health status of women were compared among the three groups. Results: The full-term newborn rate and survival rate of women in group C were 16.1% and 51.6%, which were significant lower than those of women in group A and B, but the incidences of premature delivery and aborted stillbirth of women in group C were 35.5% and 48.5%, which were significant higher than those of women in group A and B (P<0.05). The incidence of abortion and stillbirth of women in group A was 0.0%, which was significant lower than that (9.3%) of women in group B (P<0.05). Among the 120 newborns, there were 43 (35.8%) newborns with congenital syphilis, which included 3 cases (6.1%) in group A, 13 cases (33.3%) in group B, and 32 cases (84.4%) in group C, and there were significant different in the rate of newborns with congenital syphilis among the three groups (P<0.05). Before delivery, the proportions of normal newborns and newborns with congenital syphilis of women with the TRUST titer ≤ 1:4 were 79.1% and 50.0%, which were significant higher than those (13.2% and 42.7%) of women with the TRUST titer ≥ 1:8 (P<0.05). The average Apgar score of 1 min and 5 min of newborns after born in group A were 8.38±0.40 scores and 8.47±0.36 scores, which were significant higher than those of newborns (8.04±0.31 scores and 8.14±0.32 scores) in group B, and those of newborns in group A and B were significant higher than those of newborns (7.74±0.27 scores and 7.86±0.28 scores) in group C (P<0.05). Conclusion: Early syphilis diagnose and intervention of pregnant women can effectively improve the their pregnancy outcomes, and the treatment effect of syphilis during the first trimester pregnancy is better than that during the second and third trimester pregnancy.
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