Abstract Objective: To explore the detection rate of immune antibodies of infertility women, and to study its related risk factors. Methods: 61 infertile women were enrolled in study group from January 2018 to October 2018, and 61 healthy women with normal birth history were selected in control group. The detection rates of anti-β2-glycoprotein I (β2-GPI）antibody, anti-thyroid peroxidase antibody (A-TPOAb), anti-sperm antibody (AsAb), and endometrial antibody (EMAb) of women were compared between the two groups. And the related risk factors of infertility were analyzed. Results: In the study group, 18 (29.51%) women were primary infertility, 43 (70.49%) women were secondary infertility. The detection rates of anti-β2-GPI, A-TPOAb, AsAb, and EMAb of women in the study group were 24.6%, 19.7%, 23.0%, and 29.5%, respectively, which were significant higher than those of women in the control group (P<0.05). In the study group, the detection rates of anti-β2-GPI, AsAb, and EMAb of women with primary infertility were 16.4%, 14.8%, and 19.7%, respectively, which were significant higher than those of women with secondary infertility (P<0.05), but the detection rate of A-TPOAb of women with primary infertility had no different to that of women with secondary infertility. In the study group, there were 41.0% women with ovulation disorders, 29.5% women with immune factors, 21.3% women with pelvic inflammatory disease, and 19.7% women with fallopian tube lesions, which all were the main risk factors of infertility. Conclusion: The levels of anti-β2-GPI, A-TPOAb, AsAb, and EMAb of women has a close relationship with infertility, which has important significance for the diagnosiing immune infertility. The ovulation disorders, immune factors, pelvic inflammatory disease, and fallopian tube lesions are the main factors leading to infertility, so they should be paid more attention to in clinical practice.
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