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| Clinical significances of the luteal blood flow index monitored by ultrasound and the levels of peripheral blood anti-thyroid peroxidase antibodies and β-human chorionic gonadotrophin of women with threatened abortion for predicting their prognosis |
| Huai'an Rehabilitation Hospital, Huai'an, Jiangsu Province, 211600 |
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Abstract To investigate the clinical significances of the luteal blood flow index monitored by ultrasound, and the levels of peripheral blood anti-thyroid peroxidase antibodies (TPOAb) and β-human chorionic gonadotrophin (β-hCG) of women with threatened abortion for predicting their prognosis. Methods: 92 women with early threatened abortion in study group and 92 healthy pregnant women in control group from May 2019 to January 2021 were collected retrospectively. The luteal ultrasonic perfusion index (PI), resistance index (RI), and the levels of peripheral blood TPOAb and β-hCG of the women were compared between the two groups. The women in the study group were followed up and were divided into group A (women with normal prognosis) and group B (women with poor prognosis) according to the pregnancy outcomes of the women. The values of PI and RI, and the levels of TPOAb and β-hCG of the women were compared between group A and group B. The correlation between the values of PI and RI, and the levels of TPOAb and β-hCG of the women and their poor prognosis was analyzed. Results: The values of PI (0.96±0.14) and RI (2.85±0.53) of the women in the study group were significantly higher than those (0.71±0.12 and 1.75±0.48) of the women in the control group. The serum TPOAb level (221.11±1.23 IU/ml) of the women in the study group was significantly higher than that (1.89±0.57 IU/ml) of the women in the control group, but the β-hCG level (46422.85±500.53 mIU/ml) of the women in the study group was significantly lower than that (49621.75±513.48 mIU/ml) of the women in the control group. The values of BPI and RI of the women in group B were significantly higher than those of the women in group A, the serum TPOAb level of the women in group B was significantly higher than that of the women in group A, and the β-hCG level of the women in group B was significantly lower than that of the women in group A (all P<0.05). Pearson regression analysis showed the PI and RI values by luteal ultrasound and the serum TPOAb and β-hCG levels of the women with early onset threatened abortion were associated with their poor prognosis (all P<0.05). Conclusion: The luteal blood flow PI and RI values monitored by ultrasound and the peripheral blood TPOAb andβ-hCG levels of the women have clinical significances for their prognosis.
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