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| The value of serum cystatin C and uric microalbumin for evaluating the renal injury of pregnant women with hypertensive disorder complicating pregnancy#br# |
| Xiasha Hospital of Hangzhou City, Zhejiang Province, 310016 |
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Abstract Objective: To evaluate value of serum cystatin C and uric microalbumin for evaluating the renal injury of pregnant women with hypertensive disorder complicating pregnancy. Methods: 190 pregnant women with hypertensive disorder complicating pregnancy were selected as the subjects, and were divided into group A (women with gestational hypertension, group B (women with mild preeclampsia), and group B (women with severe preeclampsia), and another 100 healthy pregannat women were selected in group D during the same period. The serum levels of cystatin C and uric microalbumin of women in the four groups were detected. The levels of serum cystatin C and uric microalbumin, and glomerular filtration rate of all women for predicting their renal function injury was analyzed. Results: Among the four group, the levels of cystatin C and uric microalbumin of women in the group C were the lowest, those of women in group C were the highest, and those of women in group B were the second highest (P<0.05). The levels of creatinine and urea nitrogen of women in group B and C were significant higher than those of women in group A and D (P<0.05), but there were no significant difference in creatinine and urea nitrogen levels between group A and group D (P>0.05). The cystatin C level and uric microalbumin level of pregnant women were correlated with their glomerular filtration rate (r=-0.885, -0.943, P<0.001), and both of them could predict renal injury of pregnant women (P<0.001). The AUC, sensitivity, and specificity of cystatin C level for predicting renal injury were 0.814, 84.4%, and 72.9%, respectively. The AUC, sensitivity and specificity of uric microalbumin level for predicting renal injury were 0.747, 82.6%, and 75.7%, respectively. Conclusion: The serum levels of cystatin C and uric microalbumin can be used as early monitoring indexes of renal function of pregnant women with hypertensive disorder complicating pregnancy.
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