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| The influence of laparoscopic surgery combined with GnRH-a on subjective symptoms, sex hormone levels and pregnancy outcomes of infertility women with endometriosis |
| Obstetrics and Gynecology Hospital Affiliated to Fudan University, Shanghai, 200011 |
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Abstract Objective: To investigate the clinical efficacy of laparoscopy combined with GnRH-a for treating infertility women with endometriosis (EMT). Methods: 104 infertility women with EMT were selected and divided into two groups according to the different treatment methods (52 cases in each group). All included women were treated by laparoscopic surgery, and then the women in study group were given GnRH-a, and the women in control group were given oral contraceptives. The subjective symptoms, sex hormone levels, and antral follicles number of women was observed before and after treatment, the pregnancy rate, and the relapse rate of women were followed up. Results: The scores of pelvic symptoms, signs and subjective symptoms, and the levels of LH, FSH and E2 of women in study group were significant lower than those of women in control group in the 6th month after operation (P<0.05). There was no significant difference in AMH level between the two groups before and after operation (P>0.05). The total effective rate of study group was 92.3%, which was significant higher than that (76.9%) of control group (P<0.05). The number of AFC of women in both groups had decreased significantly in the 6th month after operation, but the number of AFC of women in study group was significant lower than that of women in control group. In 2 years after operation, the rate of natural pregnancy and fullterm delivery of women in study group were significant higher than those of women in control group, but the recurrence rate was significant lower than that of women in control group (P<0.05). The total incidence of adverse reaction of women in study group was significant higher than that of women in control group (P<0.05). Conclusion: Laparoscopy combined with GnRH-a for treating infertility women with EMT can effectively alleviate subjective symptoms, reduce estrogen and progesterone levels, protect ovarian function, prevent disease recurrence, and improve pregnancy rates.
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