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| Effect of Bushen baotai zhuyun decoction combined with dydrogesterone for treating pregnant women with threatened abortion and fetal irritability because of Shenxu |
| 1.The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an,Shanxi Province, 710061；2. BaojiCity Maternal and ChildHealthCareHospital |
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Abstract Objective: To investigate the clinical efficacy of Bushen baotai zhuyun decoction combined with dydrogesterone for treating pregnant women with threatened abortion and fetal irritability because of Shenxu. Methods: 102 pregnant women with threatened abortion and fetal irritability because of Shenxu were randomly divided into observation group and control group (51 cases in each group). The women in control group were treated by dydrogesterone, and the women in observation group were treated by Bushen baotai zhuyun decoction combined with dydrogesterone. The clinical efficacy, symptom alleviate time, and pregnancy outcomes were compared between the two groups. The syndrome scores of women were also compared before and after treatment. And the levels of serum sex hormones (P, E2,β-HCG), CA125, INHA, Th1/Th2 cytokine (INF-γ, IL-2, IL-4, IL-10) were detected. Results: The time of vaginal bleeding, abdominal pain, and back pain of women in observation group were significant shorter than those of women in control group (P<0.05). The total effective rate of observation group was 94.1%, which was significant higher than that (80.4%) of control group (P<0.05). After treatment, the TCM syndrome score of women in observation group was significant lower than that of women in control group (P<0.05). At 1 week, 2 weeks after treatment, and 12 gestational weeks, the serum levels of CA125, INF-γand IL-2 of women in observation group were significant lower than those of women in control group, while levels of INHA, P, E2 ,β-HCG,IL-4, and IL-10 were significant higher than those of women in control group (P<0.05). The successful spuc rate of women in observation group was 94.1%, which was significant higher than that (78.4%) of women in control group (P<0.05). Conclusion: Bushen baotai zhuyun decoction combined with dydrogesterone has good effectiveness for treating pregnant women with threatened abortion and fetal irritability because of Shenxu, which can improve the spuc success rate. The mechanism may be related to the regulation of maternal and child immune-endocrine hormone disorder, regulating down the CA125 level, and regulating up the INHA level.
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