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Abstract Objective:To explore the changes of immune indexes and inflammatory factors in peripheral blood of patients with ovarian cancer, and to study their clinical significance. Methods: 43 women with ovarian cancer in affiliated hospital of Chengde medical college were selected into malignant group, 55 women with benign ovarian tumors were selected into benign group, and 50 healthy women were selected into control group. The changes of Th1, Th2, Th1/Th2, regulatory T lymphocyte (Treg), and inflammatory factors, such as interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-10 (IL-10) and INF-gamma（INF-γ）of all women during different clinical stages or in each group were measured. Results: There were no significant in changes of Th1, Th2, Th1/Th2, Treg, IL-2, INF-γ, IL-6 and IL-10 of women between benign group and malignant group (P＞0.05). The levels of Th1, Th1/Th2, IL-2 and INF-γ of women in malignant group were significant lower than those of women in control group and in benign group, while the levels of Th2, Treg, IL-6 and IL-10 of women in malignant group were significant higher than those of women in control group and in benign group(P<0.05). The levels of Th1, Th1/Th2, IL-2 and INF-γ of women with stage III-IV of ovarian cancer were significant lower than those of women with phase I-II of ovarian cancer, while the levels of Th2, Treg, IL-6 and IL-10 of women with stage III-IV of ovarian cancer were significant higher than those of women with phase I-II of ovarian cancer (P<0.05). Conclusion: The immune dysfunction and inflammatory reaction in peripheral blood of women with ovarian cancer are more severe, so they have some clinical significance.
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