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| The expression of serum miR-21 of women with polycystic ovary syndrome and the relationship betwwn miR-21 expression and obesity or metabolism of glucose and lipid |
| Luohe Central Hospital, Henan Province, 462000 |
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Abstract Objective:To explore the relationship between serum miR-21 expression of women with polycystic ovary syndrome (PCOS) and their obesity or metabolism of glucose and lipid. Methods: 96 women with PCOS (in observation group) were treated in Luohe central hospital of Henan province from February 2016 to December 2017 were selected into the data. At the same time, another 60 infertility women with basal body temperature were selected into control group. Serum miR-21 expressions of women in the two groups were detected by RT-PCR. The obesity of women diagnosed by BMI > 25 kg/m2, and 96 women with PCOS were also divided into PCOS with obesity group and PCOS with normal weight group. The expressions of serum miR-21 of women in different group were analyzed and compared. Pearson correlation analysis had been used to find the correlation between miR-21 and obesity or abnormal glucose and lipid metabolism. Results: The serum miR-21 expressions of women in observation group (2.71±0.69) was significant higher than that (1.10±0.26) of women in control group (P<0.05). The serum miR-21 expressions of obesity women with PCOS (2.91±0.82) was significant higher than that (1.80±0.36) of normal weight women with PCOS (P< 0.05). The serum miR-21 of expressions of abnormal glucose and lipid metabolism women with PCOS (2.81±0.72) was significant higher than that (1.50±0.16) of normal glucose metabolism women with PCOS (P<0.05). There was a positive correlation between miR-21 and LDL-C, HOMA-IR or BMI of women in observation group (r=0.430, 0.516, 0.356, P<0.05), but there was no correlation between miR-21 and LDL-C, HOMA-IR or BMI of women in control group. Conclusion: The expression of miR-21 is up-regulated of women with PCOS, and it is associated with obesity and abnormal glucose and lipid metabolism of women with PCOS.
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