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| Change of NT-pro BNP during pregnancy and postpartum of women with pregnancy-Induced hypertension and its correlation analysis |
| Maternal and Child Health Care Hospital Of Zhengzhou, Zhengzhou, Henan Province, 450000 |
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Abstract Objective:To observe the dynamic changes of NT-pro BNP, and to explore its correlation with cardiac function of pregnant women with pregnancy-Induced hypertension. Methods: Serum NT-pro BNP concentration levels of 48 pregnant women with pregnancy-induced hypertension and 43 healthy pregnant women were measured during pregnancy and 6 weeks postpartum by electrochemiluminescence immunoassay. The left ventricular diastolic functions of all pregnant women were evaluated by color echocardiography. Results: The concentration of NT-pro BNP was closely related to the severity of pregnancy-Induced hypertension. With the gestational weeks of pregnant women increased, the NT-pro BNP concentration of pregnant women with pregnancy-Induced hypertension gradually increased, and peak of the NT-pro BNP concentration had occurred in late pregnancy stage, and then the NT-pro BNP concentration had decreased gradually 6 weeks postpartum. The mitral flow spectrum AVTI was positively correlated with NT-proBNP concentration, and EVTI was negatively correlated with NT-proBNP concentration. Conclusion: The dynamic detection of NT-pro BNP concentration can be used as a sensitive index to reflect the severity of pregnancy-Induced hypertension and the cardiac function of pregnant women, so It can provide evidence for clinical monitoring and intervention.
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