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| Analysis of distribution and drug resistance of pathogenic bacteria in reproductive system of women of childbearing age when hospital checkup |
| 1. Boao Yilings Life Conservation Center, Qionghai, Hainan Province, 571437；2. The First Affiliated Hospital of Hainan Medical University; 3.School of Tropical Medicin and Laboratory of Hainan Medical Universty |
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Abstract Objective: To investigate the distribution and drug resistance of pathogenic bacteria in reproductive system of women of childbearing age when hospital checkup. Methods: Data of 426 women of childbearing age (19 to 49 years old) from gynecological outpatient clinics in the first affiliated hospital of Hainan medical college from January 2013 to December 2017 were retrospective analyzed. All of included women had abnormal vaginal discharge, and their vaginal or cervical secretions were collected for infection detection and secretion pathogen culture. The antimicrobial susceptibility test of bacterial culture positive samples were conducted by MIC method or Kirby Bauer paper diffusion method. The incidence of reproductive system infection, pathogen type and its composition ratio, and situation of drug resistant of women of childbearing age were statistics analyzed. Results: 382 women with reproductive system infection were diagnosed in 426 included women, which accounted for 89.7%. A total of 415 strains were detected, of which 206 strains (49.6%) were Gram positive bacteria, 71 strains (17.1%) were Gram negative bacteria, and 138 strains (33.3%) were fungi, and which mainly included coagulase negative staphylococci, Escherichia coli, and Candida albicans. Coagulase negative staphylococci were resistant to ampicillin, penicillin, erythromycin, and clindamycin, and were sensitive to amikacin, vancomycin, and teicoplanin. Escherichia coli were resistant to ampicillin, ciprofloxacin and levofloxacin, and were sensitive to imipenem and amikacin. Candida albicans amphotericin B, flucytosine sensitive, but had a certain degree of resistance to fluconazole, voriconazole, itraconazole. Univariate analysis showed that age, birth history, contraception, history of abortion, and history of previous reproductive tract infection were the relevant factors of genital tract infection (P<0.05). Multivariate regression analysis showed age, birth history, contraception, abortion history, or the history of previous reproductive tract infections was also the independent risk factor for genital tract infection. Conclusion: There are many related factors to reproductive system infection of women of childbearing age. And the pathogen flora is complex, and there is a certain resistance to conventional antibiotics. So clinical pathogens examination should be paid attention to, and drugs should be targeted and rational used.
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