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| The clinical significance of detecting serum ferritin and TNF-α, CRP and IFN-γ of patients with preeclampsia |
| Yichang Maternal and Child Health Care Hospital, Yichang, Hubei |
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Abstract Objective: To explore clinical significance of levels of serum ferritin, TNF-α (tumor necrosis factor-α), CRP (C-reactive protein) and IFN-γ (interferon-γ) of patients with preeclampsia. Methods: 68 pregnant women with preeclampsia in Yichang maternal and child health care hospital were included in study group, and another 50 healthy pregnant women were selected in control group. The levels of serum Hb (Hemoglobin), Alb (plasma albumin), Tp (total plasma protein), serum ferritin, TNF-α, CRP and IFN-γof pregnant women in both groups were detected by ELISA. Then the correlation between each serum index and pregnancy outcomes of patients with preeclampsia was analyzed. Results: The average levels of Hb, Alb, and Tp of patients in study group had no significant different from those of patients in control group (P>0.05). But in study group, the average levels of Alb and Tp of patients with moderate or severe preeclampsia were significant lower than those of patients with mild preeclampsia (P <0.05). Compared with those of patients in control group, levels of serum ferritin, TNF-α, CRP, and IFN-γof patients in study group were significant higher (P<0.05). And in study group, the levels of ferritin, TNF-α, CRP and IFN-γof patients with severe preeclampsia were significant higher than those patients with mild preeclampsia (P<0.05). The levels of TNF-α, CRP, and IFN-γ of patients with different onset time of preeclampsia had significant different (P<0.05), which included that the levels of TNF-α, CRP, and IFN-γof patients with early onset of preeclampsia were highest, and those of patients with late onset of preeclampsia were lowest. The levels of serum ferritin, TNF-α, CRP, and IFN-γof patients with adverse pregnancy outcomes were significantly higher than those of patients with normal pregnancy outcomes (P<0.05). Conclusion: The occurrence and development of preeclampsia are closely related to the increase of levels of serum ferritin and inflammatory cytokines, such as TNF-α, CRP and IFN-γ, so the pregnancy outcomes of patient can be predicted by monitoring the levels of serum ferritin, TNF-α, CRP and IFN-γin clinical practice.
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