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Abstract Objective: To explore the impact of long GnRH agonist protocol in early follicular phase on clinical outcomes of patients with polycystic ovary syndrome (PCOS) who undergone in vitro fertilizationembryo transfer (IVF- ET). Methods: Retrospective analysis was performed on patients with PCOS who had undergone IVF-ET for the first time in the second hospital of Hebei medical university from January 2016 to December 2017. The protocol of long GnRH agonist in early follicle period (folicle group) was used in 226 cycles, which was compared with the protocol of long GnRH agonist in luteal phase (114 cycles, luteal phase group) or GnRH antagonist protocol (30 cycles, GnRH antagonist group). The clinical outcomes of women in the three groups were compared. Results: Compared with those of women in luteal phase group, Gn used duration, total Gn dosage, endometrium thickness on HCG day, and the clinical pregnancy rate, and implantation rate of women in long protocol group were significant higher (P<0.05), but the available embryo number and available embryo rate were significant lower (P<0.05). Compared with those of women in GnRH antagonist group, Gn used duration, endometrium thickness on HCG day, available embryo number, and available embryo rate of women in long protocol group were significant higher (P<0.05), but there were no significant difference in the number of retrieval oocytes, clinical pregnancy rate and implantation rate of women between long protocol group and GnRH antagonist group (P>0.05). The rate of OHSS among the three groups had no significant difference (P>0.05). Conclusion: The GnRH agonist long protocol in early follicular phase maybe help to improve endometrial receptivity, thereby can help to improve the clinical outcomes of patients with PCOS.
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