|
|
|
| Clinical observation of Shenqi Jiangtang granule combined with insulin aspart injection for treating women with gestational diabetes |
| 1.Zhoushan hospital of Zhejiang Province, Zhejiang, 316000; 2. Zhoushan Maternal and Child Health Care Hospital of Zhejiang Province. |
|
|
|
|
Abstract Objective: To observe the clinical effect of Shenqi Jiangtang granule combined with insulin aspart injection for treating women with gestational diabetes. Methods: 190 women with gestational diabetes mellitus(GDM) in department of gynecology and obstetrics of Zhoushan hospital were selected as research subjects from September 2014 to September 2016, and all the pregnant women were randomized divided into study group (95 cases) and control group (95 cases) according to the random number table. The pregnant women in control group were treated by insulin aspart injection only, and the pregnant women in study group were given oral administration of shenqi jiangtang granule except insulin aspart injection. The occurrence of adverse reactions of drugs during the treatment, the average dosage of insulin aspartate and the period of blood glucose up to standard of pregnant women in both groups were observed, and the blood glucose and glycosylated hemoglobin level after treatment were compared between the two groups. And the curative effect, rate of adverse pregnant outcomes, and rate of perinatal complications were evaluated between the two groups. Results: During the treatment, the average amount of insulin aspart used of women in study group(38.6±4.4) IU/d was significant lower than that of women in control group (52.7±6.3) IU/d, and the time of blood glucose up to standard of women in study group (4.5±1.1) d was significantly shorter than that of women(7.6±1.8) d in control group (P<0.05). There was no significant different in the incidence of adverse reactions of drugs between study group (8.4%) and control group (12.6%) (P=0.12). After treatment, the levels of preprandial and postprandial 2h blood sugar and glycated hemoglobin of women were significant lower than those of women before the treatment in the both groups (P<0.05), but there was no significant different in levels of preprandial blood glucose, postprandial 2h blood glucose and glycated hemoglobin of women between the two groups (P>0.05). The total effective rate of gestational diabetes in study group (96.8%) was significantly higher than that in control group (85.3%) (P<0.05). The incidence of cesarean section, premature birth and abortion of women in study group (30.5%, 2.1% and 3.2%, respectively) were significantly lower than those of women in control group (44.2%, 13.7% and 11.6%, respectively) (P<0.05), and the incidence of perinatal complications of women in study group (7.4%) was significantly lower than that of women in control group (26.3%) (P<0.05). Conclusion: Insulin injection combined Shenqi jiangtang granule for treating women with GDM can significantly improve the overall effect, decrease the dosage of insulin injection, shorten the time of blood glucose up to standard, improve pregnancy outcomes, reduce rate of perinatal complications, and don’t increase rate of adverse reactions of drugs.
|
|
|
|
|
|
|
|
|
