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Abstract Objective: To investigate the effectiveness of Lthyroxine tablets on pregnant women with hypothyroidism, and to explore its effect on intelligence development of children. Methods: From January 2013 to January 2014, 86 pregnant women with hypothyroidism in Liuzhou maternal and child health care hospital were randomly divided into group A and group B (43 cases in each group), while another 50 healthy pregnant women who delivered in the same period was in control group. Pregnant women in group B were given conventional treatment, and pregnant women in group A were treated with levothyroxine except the basis of treatment in group B. The clinical efficacy was compared between group A and group B. Level of FT3, FT4, TSH, and folic acid of all women were compared before and after treatment. And outcomes of maternal and infant and pregnant complications were also compared among the three groups. After 3 years of followup, gesell scale was used to measure the mental development of children at 3 years old in the three groups. Results: The total effective rate of group A was 95.35% (41/43), which was significantly higher than that of group B (81.40%, 35/43) (P <0.05). Level of folic acid and TSH of women in group A were significantly lower than those of women in group B, but the level of FT3 and FT4 of women were significantly higher than those of women in group B (P<0.05). Compared with group B, the incidence of complications of pregnancy of women in group A decreased significantly, the incidence of fetal growth retardation, premature birth and aborted fetus also significantly decreased, and Apgar score and birth weight significantly increased (P<0.05). The data of followup 3 years had showed that the success rate of followup of group A was 81.40% (35/43), that of group B was and that of control group was 76.00% (38/50). The scores of LQ, ABQ, GMQ, ISBQ and FMQ of children in the three groups were significantly different (P <0.05), but there was no significant difference in score between A group and control group (P> 0.05), and the score of children in B group was significantly lower than of children in A Group and in control group (P<0.05). Conclusion: There is perfect effectiveness of levothyroxine for treating pregnant women with hypothyroidism, which can significantly improve pregnant outcome of maternal and infant, reduce complications during pregnancy, and can contribute to intellectual development of children.
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