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| Clinical significance of changes of α1MG, CRP and DD in blood of pregnant women with hypertension |
| Maternal and Child Health Hospital of Changxing County, Zhejiang |
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Abstract Objective: To investigate the clinical value of serum α1microglobulin (α1MG), Creactive protein (CRP) and plasma D dimer (DD) in the diagnosis of gestational hypertensive disorders of pregnant women. Methods: A total of 128 pregnant women with gestational hypertension admitted to maternal and child health hospital of Changxing county from July 2014 to April 2017 were enrolled in this study. 60 healthy pregnant women and 45 healthy women without pregnancy were selected as the control group. The levels of α1MG, CRP and DD in sera of all subjects were detected and to assess the value of level of α1MG, CRP and DD for diagnosing pregnancyinduced hypertension. Results: The levels of α1MG, CRP and DD in pregnant women with pregnancyinduced hypertension were significantly higher than those of healthy pregnant women and healthy women without pregnancy (P<0.05), but there was no significantly different between healthy pregnant women and healthy women without pregnancy (P> 0.05). The levels of α1MG, CRP and DD of pregnant women with eclampsia were significantly higher than those of pregnant women with severe preeclampsia, and the levels of α1MG, CRP and DD of pregnant women with severe preeclampsia were significantly higher than those of pregnant women with mild preeclampsia (P<0.05). Conclusion: The levels of α1MG, CRP and DD in blood of pregnant women with gestational hypertension increase, and are related to the severity of the disease, so which can be used as early clinical diagnostic indicators for dignosing gestational hypertension, and can dynamic monitor the disease progression.
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