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| Changes and detecting significance of serum mALB, Urea, NGAL and CysC of pregnant women with early renal injury because of pregnancyinduced hypertension syndrome |
| Lanzhou Maternal and Child Health Care Hospital of Gansu Province, Gansu |
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Abstract Objective: To explore the changes and detecting significance of serum mALB, Urea, NGAL and Cys-C of pregnant women with early renal injury because of pregnancy-induced hypertension syndrome. Methods: Eighty pregnant women with pregnancyinduced hypertension syndrome from Lanzhou maternal and child health care hospital were recruited into this study from September 2015 to August 2017, which included 27 patients with pregnancyinduced hypertension, 26 patients with mild preeclampsia, 27 patients with severe preeclampsia. At the same time, the 80 cases were also divided into normal renal function group (41 cases) and renal insufficiency group (39 cases) bade on the value of creatinine clearance. Except that, 80 normal pregnant women were included in normal control group. The levels of serum mALB, Urea, NGAL and CysC of all included women were detected. And the changes of level of mALB, Urea, NGAL and CysC were analyzed, and the relationship between level of mALB, Urea, NGAL and CysC and renal injury was also explored. Results: The levels of serum mALB, Urea, NGAL and CysC of women in observation group were significant higher than those of women in control group (P<0.05). The levels of serum mALB, Urea, NGAL and CysC of women with severe preeclampsia were significant higher than those of women with pregnancyinduced hypertension or mild preeclampsia (P <0.05). The levels of serum mALB, Urea, NGAL and CysC of women with abnormal renal function were significant higher than those of women with normal renal function (P <0.05). Conclusion: The level of serum mALB, Urea, NGAL and CysC increases with the pregnancyinduced hypertension syndrome becoming more severity. Combined detecting the levels of serum mALB, Urea, NGAL and CysC of women with pregnancyinduced hypertension are beneficial to diagnose renal injury early, and has significance for clinical treatment.
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