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| Comparison of clinical efficacy and safety of misoprostol tablets with oxytocin for inducing labor of pregnant women with scar pregnancy |
| Renqiu City People's Hospital of Hebei Province, Hebei |
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Abstract Objective: To compare the clinical efficacy and safety of misoprostol tablets with oxytocin for inducing labor of pregnant women with scar pregnancy. Methods: A total of 144 pregnant women with cicatricial uterus pregnancy, who were suitable for vaginal trial labor, were randomly divided into three groups (48 cases in control group, misoprostol group and oxytocin group). The women in misoprostol group received vaginal misoprostol tablets, the women in oxytocin group were given intravenous infusion of oxytocin, and the women in control group were given natural childbirth. Cervical maturation, parturient duration, delivery mode, prognosis of maternal and child were compared among the three groups. Results: The first, Bishop score of pregnant women in the three groups had significant different at 4h, 8h, 12h and 24h after treatment (P <0.05), and the Bishop score of pregnant women in misoprostol group was significant higher than that of pregnant women in oxytocin group (P <0.05). The second, the labor time, total parturient duration, and rate of vaginal birth of pregnant women in three groups had significant different (P <0.05). The labor time and total parturient duration of pregnant women in misoprostol group were significant shorter than those of pregnant women in oxytocin group (P >0.05), but rate of vaginal birth of pregnant women in misoprostol group and in oxytocin group had no significant different (P >0.05). The third, the total incidence of postpartum complications of pregnant women in the three groups had statistical significant different (P <0.05), but there was no significant difference of pregnant in women incidence of postpartum complications between misoprostol group and oxytocin group (P >0.05). The fourth, the total incidence of neonatal complications had statistical significant different among the three groups (P <0.05), but there was no significant difference between misoprostol group and oxytocin group (P >0.05). Conclusion：Misoprostol tablets and oxytocin can promote the maturation of maternal cervix uteri, shorten parturient duration, and reduce the risk of cesarean delivery of pregnant women with scar uterine pregnancy. Both of misoprostol and oxytocin have a similar effect on prognosis of maternal and child, but misoprostol has better effect to promote the maturation of maternal cervix uteri and to shorten parturient duration.
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