|
Abstract Objective: To explore the effect of the decline of serum estradiol between human chorionic gonadotropin (hCG) injection day and 48 h after ovum pick-up (OPU) on pregnancy outcomes during controlled ovarian hyperstimulation (COH) of embryo transfer in cleavage stage. Methods: In this retrospectively study, 5048 in vitro fertilization/intracytoplasmic sperm injection and day-3 embryo transfer (IVF/ICSI-ET) cycles were performed. According to the declining level of serum estradiol, day-3 embryo transfer cycles were respectively divided into 3 groups, with the decline of estradiol level of ≤60%, 60%-80% and >80%, respectively. The clinical pregnancy outcomes were compared among groups. Results: The clinical pregnancy rates in A, B and C groups were 51.8% (320/618), 51.65 (1803/3491) and 45.9% (432/940), respectively (P<0.05). Of these three groups, early spontaneous abortion rates were 9.1% (29/320), 10.5% (191/1803) and 15.5% (67/432), and ectopic pregnancy rates were 2.8% (9/320), 3.4% (61/1803) and 8.5% (87/432)，respectively, showing significant differences (P all <0.05). Conclusion: Higher declining level of serum estradiol between hCG injection day and 48 h after OPU could result in higher incidence of early abortion rates and ectopic pregnancy rates in embryo transfer of the cleavage stage.
|
|
|
|
|
|
