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Abstract Objective: To explore the short-term effects of low dose of nitrite sodium on male reproduction. Methods: SPF Kunming mice were randomly divided into normal group, background group, low-dose group, middle-dose and high-dose group. The weight of main organs was measured and organ coefficient was calculated. Sperm count, sperm survival rate, sperm activity were analyzed. Results: compared with the normal group, organ coefficient of liver and spleen increased significantly, the epididymis coefficient decreased, sperm count and sperm activity decreased significantly. The ratio of C grade sperm decreased significantly, but the ratio of A , B grade sperm did not changed obviously. Compared with the normal group, testis with nitrite exposure was damaged at different degree. Conclusion: The short-term exposure of nitrite sodium would lead to liver, spleen and epididymis damage. The sperm count and sperm activity decrease with increasing dose of nitrite sodium. Low-dose and short-term nitrite sodium exposure can damage the reproductive function of male mice.
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LI Huanhuan1, TE Liger2, MA Jing1, BI Jiajie3, LI Yuejia2, ZHEN Yinxian1, WANG Shusong1. Effects of zinc supplementation for rats fed with high fat diet on their circRNA, microRNA, and mRNA network in the testicular tissue[J]. 中国计划生育学杂志, 2023, 31(7): 1506-. |
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